BDBM50222869 6-(4-fluorophenoxy)-3-{[(3S)-1-isopropylpiperidin-3-yl]methyl}-2-methylquinazolin-4(3H)-one::CHEMBL243001

SMILES CC(C)N1CCC[C@H](Cn2c(C)nc3ccc(Oc4ccc(F)cc4)cc3c2=O)C1

InChI Key InChIKey=FRKXOBMDEXCHHD-SFHVURJKSA-N

Data  3 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50222869   

TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50222869(6-(4-fluorophenoxy)-3-{[(3S)-1-isopropylpiperidin-...)
Affinity DataKi:  4nMAssay Description:Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Ovis aries)
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50222869(6-(4-fluorophenoxy)-3-{[(3S)-1-isopropylpiperidin-...)
Affinity DataKi:  17nMAssay Description:Displacement of [125I]ghrelin from ovine recombinant GHSR1a expressed in HEK293F cells after 6 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50222869(6-(4-fluorophenoxy)-3-{[(3S)-1-isopropylpiperidin-...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [125I]DIO from 5HT2c receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50222869(6-(4-fluorophenoxy)-3-{[(3S)-1-isopropylpiperidin-...)
Affinity DataIC50:  1.62E+3nMAssay Description:Inhibition of human Erg by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50222869(6-(4-fluorophenoxy)-3-{[(3S)-1-isopropylpiperidin-...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed