BDBM50224221 5-cyclopentyl-2-(2-fluorophenylamino)thiazol-4(5H)-one::CHEMBL240269

SMILES Oc1nc(Nc2ccccc2F)sc1C1CCCC1

InChI Key InChIKey=YHZJXPZWKDRZOT-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50224221   

Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50224221(5-cyclopentyl-2-(2-fluorophenylamino)thiazol-4(5H)...)
Affinity DataKi:  5.30nMAssay Description:Inhibition of human 11betaHSD1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50224221(5-cyclopentyl-2-(2-fluorophenylamino)thiazol-4(5H)...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human 11betaHSD1 in CHO cells assessed as conversion of cortisone to cortisolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50224221(5-cyclopentyl-2-(2-fluorophenylamino)thiazol-4(5H)...)
Affinity DataIC50:  380nMAssay Description:Inhibition of human 11betaHSD2 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed