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BDBM50228427 (R)-N-[(S)-1-(4-guanidino-benzylcarbamoyl)-ethyl]-3-hydroxy-2-phenylmethanesulfonylamino-propionamide::CHEMBL238902::N-(BENZYLSULFONYL)-D-SERYL-N-(4-{[AMINO(IMINO)METHYL]AMINO}BENZYL)-L-ALANINAMIDE

SMILES: [#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H](-[#6]-[#8])-[#7]S(=O)(=O)[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6]-c1ccc(cc1)\[#7]=[#6](\[#7])-[#7]

InChI Key: InChIKey=GIFIGLJPDYSYDF-KBXCAEBGSA-N

Data: 3 KI

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50228427   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50228427
PNG
((R)-N-[(S)-1-(4-guanidino-benzylcarbamoyl)-ethyl]-...)
Show SMILES C[C@H](NC(=O)[C@@H](CO)NS(=O)(=O)Cc1ccccc1)C(=O)NCc1ccc(cc1)N=C(N)N
Show InChI InChI=1S/C21H28N6O5S/c1-14(19(29)24-11-15-7-9-17(10-8-15)26-21(22)23)25-20(30)18(12-28)27-33(31,32)13-16-5-3-2-4-6-16/h2-10,14,18,27-28H,11-13H2,1H3,(H,24,29)(H,25,30)(H4,22,23,26)/t14-,18+/m0/s1
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PDB
Article
PubMed
16n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA


J Med Chem 50: 6638-46 (2007)


Article DOI: 10.1021/jm700962j
BindingDB Entry DOI: 10.7270/Q2MW2J0J
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tissue-type plasminogen activator


(Homo sapiens (Human))
BDBM50228427
PNG
((R)-N-[(S)-1-(4-guanidino-benzylcarbamoyl)-ethyl]-...)
Show SMILES C[C@H](NC(=O)[C@@H](CO)NS(=O)(=O)Cc1ccccc1)C(=O)NCc1ccc(cc1)N=C(N)N
Show InChI InChI=1S/C21H28N6O5S/c1-14(19(29)24-11-15-7-9-17(10-8-15)26-21(22)23)25-20(30)18(12-28)27-33(31,32)13-16-5-3-2-4-6-16/h2-10,14,18,27-28H,11-13H2,1H3,(H,24,29)(H,25,30)(H4,22,23,26)/t14-,18+/m0/s1
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Article
PubMed
>2.50E+3n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human recombinant tPA


J Med Chem 50: 6638-46 (2007)


Article DOI: 10.1021/jm700962j
BindingDB Entry DOI: 10.7270/Q2MW2J0J
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))
BDBM50228427
PNG
((R)-N-[(S)-1-(4-guanidino-benzylcarbamoyl)-ethyl]-...)
Show SMILES C[C@H](NC(=O)[C@@H](CO)NS(=O)(=O)Cc1ccccc1)C(=O)NCc1ccc(cc1)N=C(N)N
Show InChI InChI=1S/C21H28N6O5S/c1-14(19(29)24-11-15-7-9-17(10-8-15)26-21(22)23)25-20(30)18(12-28)27-33(31,32)13-16-5-3-2-4-6-16/h2-10,14,18,27-28H,11-13H2,1H3,(H,24,29)(H,25,30)(H4,22,23,26)/t14-,18+/m0/s1
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Article
PubMed
4.00E+4n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human plasmin


J Med Chem 50: 6638-46 (2007)


Article DOI: 10.1021/jm700962j
BindingDB Entry DOI: 10.7270/Q2MW2J0J
More data for this
Ligand-Target Pair