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BDBM50228829 CHEMBL2111611

SMILES: COc1ccc(cc1O[C@H]1CC2CCC1C2)C1CNC(=O)N1C

InChI Key: InChIKey=GCEUBBGDHJJDSY-IWYBDHIPNA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50228829   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228829
PNG
(CHEMBL2111611)
Show SMILES COc1ccc(cc1O[C@H]1CC2CCC1C2)C1CNC(=O)N1C
Show InChI InChI=1/C18H24N2O3/c1-20-14(10-19-18(20)21)12-5-6-15(22-2)17(9-12)23-16-8-11-3-4-13(16)7-11/h5-6,9,11,13-14,16H,3-4,7-8,10H2,1-2H3,(H,19,21)/t11?,13?,14?,16-/s2
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 460n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of cAMP-specific calcium-independent phosphodiesterase (IPDE).


J Med Chem 34: 291-8 (1991)


Article DOI: 10.1021/jm00105a045
BindingDB Entry DOI: 10.7270/Q2NV9MG8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228829
PNG
(CHEMBL2111611)
Show SMILES COc1ccc(cc1O[C@H]1CC2CCC1C2)C1CNC(=O)N1C
Show InChI InChI=1/C18H24N2O3/c1-20-14(10-19-18(20)21)12-5-6-15(22-2)17(9-12)23-16-8-11-3-4-13(16)7-11/h5-6,9,11,13-14,16H,3-4,7-8,10H2,1-2H3,(H,19,21)/t11?,13?,14?,16-/s2
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.70n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]- rolipram binding to phosphodiesterase 4 of rat cerebral cortex membranes.


J Med Chem 34: 291-8 (1991)


Article DOI: 10.1021/jm00105a045
BindingDB Entry DOI: 10.7270/Q2NV9MG8
More data for this
Ligand-Target Pair