BDBM50229191 CHEMBL252409::US9096559, 15::[4-(4-amino-biphenyl-3-ylcarbamoyl)-benzyl]-carbamic acid benzyl ester

SMILES Nc1ccc(cc1NC(=O)c1ccc(CNC(=O)OCc2ccccc2)cc1)-c1ccccc1

InChI Key InChIKey=XNNFDOVUKNVDRN-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50229191   

TargetHistone deacetylase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50229191(CHEMBL252409 | US9096559, 15 | [4-(4-amino-bipheny...)
Affinity DataIC50:  58nMAssay Description:Novel compounds were tested for their ability to inhibit histone deacetylase, subtype 1 (HDAC1) using an in vitro deacetylation assay. The enzyme sou...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50229191(CHEMBL252409 | US9096559, 15 | [4-(4-amino-bipheny...)
Affinity DataIC50:  17nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50229191(CHEMBL252409 | US9096559, 15 | [4-(4-amino-bipheny...)
Affinity DataIC50:  1.45E+4nMAssay Description:Inhibition of human recombinant HDAC1 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 5 mins measured after 35 mins by spectrofl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50229191(CHEMBL252409 | US9096559, 15 | [4-(4-amino-bipheny...)
Affinity DataIC50:  740nMAssay Description:Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 24 hrs measured after 35 mins by spectrofl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50229191(CHEMBL252409 | US9096559, 15 | [4-(4-amino-bipheny...)
Affinity DataIC50:  3.80E+4nMAssay Description:Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 5 mins measured after 35 mins by spectrofl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50229191(CHEMBL252409 | US9096559, 15 | [4-(4-amino-bipheny...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 3 hrs measured after 35 mins by spectroflu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50229191(CHEMBL252409 | US9096559, 15 | [4-(4-amino-bipheny...)
Affinity DataIC50:  1.88E+3nMAssay Description:Inhibition of human recombinant HDAC1 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 3 hrs measured after 35 mins by spectroflu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed