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BDBM50232161 CHEMBL4091622

SMILES: Oc1ccc(F)c(C(=O)c2ccc(s2)-c2ccncc2)c1F

InChI Key: InChIKey=BVGMSNSBQLORRI-UHFFFAOYSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50232161   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Estradiol 17-beta-dehydrogenase 2


(Homo sapiens (human))
BDBM50232161
PNG
(CHEMBL4091622)
Show SMILES Oc1ccc(F)c(C(=O)c2ccc(s2)-c2ccncc2)c1F
Show InChI InChI=1S/C16H9F2NO2S/c17-10-1-2-11(20)15(18)14(10)16(21)13-4-3-12(22-13)9-5-7-19-8-6-9/h1-8,20H
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

PubMed
n/an/a 39n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of human placental microsomal 17beta-HSD2 using [2,4,6,7-3H]-E2 as substrate after 20 mins in presence of NAD+ by RP-HPLC method


Eur J Med Chem 127: 944-957 (2017)

More data for this
Ligand-Target Pair
Estradiol 17-beta-dehydrogenase 1


(Homo sapiens (Human))
BDBM50232161
PNG
(CHEMBL4091622)
Show SMILES Oc1ccc(F)c(C(=O)c2ccc(s2)-c2ccncc2)c1F
Show InChI InChI=1S/C16H9F2NO2S/c17-10-1-2-11(20)15(18)14(10)16(21)13-4-3-12(22-13)9-5-7-19-8-6-9/h1-8,20H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

PubMed
n/an/a 150n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of human placental cytosolic 17beta-HSD1 assessed as reduction in activation of [2,4,6,7-3H]-E1 substrate to E2 after 10 mins in presence ...


Eur J Med Chem 127: 944-957 (2017)

More data for this
Ligand-Target Pair