BDBM50232566 5-(3-chlorobenzyloxy)quinazoline-2,4-diamine::CHEMBL250231

SMILES Nc1nc(N)c2c(OCc3cccc(Cl)c3)cccc2n1

InChI Key InChIKey=XPEAWFARHPCLQT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50232566   

Targetm7GpppX diphosphatase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50232566(5-(3-chlorobenzyloxy)quinazoline-2,4-diamine | CHE...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232566(5-(3-chlorobenzyloxy)quinazoline-2,4-diamine | CHE...)
Affinity DataIC50:  9.80E+4nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed