BDBM50235282 CHEMBL4077967

SMILES CN(C)Cc1ccc2ccc(Cl)c(C3=C(C(=O)NC3=O)c3cn(C)c4ccccc34)c2c1

InChI Key InChIKey=GDZULWKNFKCRJP-UHFFFAOYSA-N

Data  2 KI  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50235282   

TargetProtein kinase C beta type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50235282(CHEMBL4077967)
Affinity DataKi:  0.5nMAssay Description:Reversible competitive inhibition of PKCbeta1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50235282(CHEMBL4077967)
Affinity DataKi:  1nMAssay Description:Reversible competitive inhibition of PKCalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50235282(CHEMBL4077967)
Affinity DataIC50:  4nMAssay Description:Inhibitory concentration against [3H]dopamine uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50235282(CHEMBL4077967)
Affinity DataIC50:  214nMAssay Description:Inhibition of PKCdelta (unknown origin) after 60 mins in presence of [gamma33P]ATP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50235282(CHEMBL4077967)
Affinity DataIC50:  263nMAssay Description:Inhibition of PKCtheta (unknown origin) after 60 mins in presence of [gamma33P]ATP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50235282(CHEMBL4077967)
Affinity DataIC50:  402nMAssay Description:Compound was tested for its ability to inhibit porcine pancreas phospholipase-A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50235282(CHEMBL4077967)
Affinity DataIC50:  220nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50235282(CHEMBL4077967)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of PKCbeta1 (unknown origin) after 60 mins in presence of [gamma33P]ATP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50235282(CHEMBL4077967)
Affinity DataIC50:  402nMAssay Description:Inhibition of PKCtheta in human Jurkat T cells assessed as reduction in anti-CD3/CD28 antibody-induced T-cell activation by measuring decrease in IL-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C eta type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50235282(CHEMBL4077967)
Affinity DataIC50:  565nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Rattus norvegicus (rat))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50235282(CHEMBL4077967)
Affinity DataIC50:  296nMAssay Description:Inhibition of PKCbeta in mouse B cells assessed as reduction in IgM-stimulated cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed