BindingDB logo
myBDB logout

BDBM50236226 CHEMBL4087412

SMILES: Cc1cc(C2CCCN(C2)C(=O)c2ccc3CCOc3c2)n2ncnc2n1

InChI Key: InChIKey=VOQJMNVKRKGOBN-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50236226   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50236226
PNG
(CHEMBL4087412)
Show SMILES Cc1cc(C2CCCN(C2)C(=O)c2ccc3CCOc3c2)n2ncnc2n1
Show InChI InChI=1S/C20H21N5O2/c1-13-9-17(25-20(23-13)21-12-22-25)16-3-2-7-24(11-16)19(26)15-5-4-14-6-8-27-18(14)10-15/h4-5,9-10,12,16H,2-3,6-8,11H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 3n/an/an/an/an/an/a



Dart Neuroscience LLC

Curated by ChEMBL


Assay Description
Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...


J Med Chem 60: 2037-2051 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01793
BindingDB Entry DOI: 10.7270/Q2Q242GF
More data for this
Ligand-Target Pair