BDBM50236282 CHEMBL4104895

SMILES Cl.CC1(C)N=C(N)N=C(N)N1OCCOc1cccc(c1)C(=O)\C=C\c1ccccc1

InChI Key InChIKey=AYAVEBPLSLPUBI-VAWYXSNFSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50236282   

TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236282(CHEMBL4104895)
Affinity DataIC50:  36nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in conversion of DHF to THF measured every 30 secs for 6 mins by UV-Vis spectrophotometric...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236282(CHEMBL4104895)
Affinity DataIC50:  1.08E+4nMAssay Description:Inhibitory concentration against Farnesyltransferase for Farnesylation of H-ras protein InNIH 3T3 cells transformed with activated H-rasMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236282(CHEMBL4104895)
Affinity DataIC50:  6.90E+3nMAssay Description:Inhibition of recombinant rat liver thioredoxin reductase after 60 mins by DTNB reduction assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed