BDBM50237536 6-Shogaol::CHEBI:10138::SHOGAOL::Trans-6-Shogaol

SMILES CCCCC\C=C\C(=O)CCc1ccc(O)c(OC)c1

InChI Key InChIKey=OQWKEEOHDMUXEO-BQYQJAHWSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50237536   

TargetCytochrome P450 1A2(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50237536(6-Shogaol | CHEBI:10138 | SHOGAOL | Trans-6-Shogao...)
Affinity DataIC50:  2.07E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50237536(6-Shogaol | CHEBI:10138 | SHOGAOL | Trans-6-Shogao...)
Affinity DataIC50:  8.33E+4nMAssay Description:Inhibition of CYP2A6 in human liver microsomes using Coumarin as substrate preincubated for 10 mins followed by NADPH addition measured after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50237536(6-Shogaol | CHEBI:10138 | SHOGAOL | Trans-6-Shogao...)
Affinity DataIC50:  3.30E+3nMAssay Description:Binding affinity towards human Melanocortin 1 receptor (hMC1R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50237536(6-Shogaol | CHEBI:10138 | SHOGAOL | Trans-6-Shogao...)
Affinity DataIC50:  7.61E+4nMAssay Description:Inhibition of CYP2E1 in human liver microsomes using chlorzoxazone as substrate preincubated for 10 mins followed by NADPH addition measured after 20...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50237536(6-Shogaol | CHEBI:10138 | SHOGAOL | Trans-6-Shogao...)
Affinity DataIC50:  2.92E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50237536(6-Shogaol | CHEBI:10138 | SHOGAOL | Trans-6-Shogao...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate preincubated for 10 mins followed by NADPH addition measured after 10 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50237536(6-Shogaol | CHEBI:10138 | SHOGAOL | Trans-6-Shogao...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of recombinant human CYP3A4 expressed in baculosomes using Vivid BOMR substrate red measured every 30 sec for 30 mins by fluorescence assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50237536(6-Shogaol | CHEBI:10138 | SHOGAOL | Trans-6-Shogao...)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using amodiaquin as substrate preincubated for 10 mins followed by NADPH addition measured after 10 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50237536(6-Shogaol | CHEBI:10138 | SHOGAOL | Trans-6-Shogao...)
Affinity DataIC50:  1.88E+4nMAssay Description:In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC1R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50237536(6-Shogaol | CHEBI:10138 | SHOGAOL | Trans-6-Shogao...)
Affinity DataIC50:  6.52E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 10 mins followed by NADPH addition measured after 5 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50237536(6-Shogaol | CHEBI:10138 | SHOGAOL | Trans-6-Shogao...)
Affinity DataIC50:  9.96E+4nMAssay Description:Inhibition of CYP2E1 in human liver microsomes using chlorzoxazone as substrate by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50237536(6-Shogaol | CHEBI:10138 | SHOGAOL | Trans-6-Shogao...)
Affinity DataIC50:  5.80E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 10 mins followed by NADPH addition measured after 20 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50237536(6-Shogaol | CHEBI:10138 | SHOGAOL | Trans-6-Shogao...)
Affinity DataIC50:  8.70E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 10 mins followed by NADPH addition measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50237536(6-Shogaol | CHEBI:10138 | SHOGAOL | Trans-6-Shogao...)
Affinity DataIC50:  8.30E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate preincubated for 10 mins followed by NADPH addition measured after 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed