BDBM50239432 CHEMBL4104747

SMILES CC(C)(C)C1CCc2c(C1)sc(NC(=O)c1ccco1)c2C(O)=O

InChI Key InChIKey=ACLUEOBQFRYTQS-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50239432   

TargetAnoctamin-1(Homo sapiens (Human))
San Francisco State University

Curated by ChEMBL
LigandPNGBDBM50239432(CHEMBL4104747)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
San Francisco State University

Curated by ChEMBL
LigandPNGBDBM50239432(CHEMBL4104747)
Affinity DataIC50:  1.31E+3nMAssay Description:Inhibition of human ANO1 channel expressed in HEK293 cells incubated for 10 mins by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
San Francisco State University

Curated by ChEMBL
LigandPNGBDBM50239432(CHEMBL4104747)
Affinity DataIC50:  7.57E+3nMAssay Description:Inhibition of YFP tagged ANO1 (unknown origin) expressed in FRT cells incubated for 24 hrs by fluorescence plate reader assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAnoctamin-1(Homo sapiens (Human))
San Francisco State University

Curated by ChEMBL
LigandPNGBDBM50239432(CHEMBL4104747)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of ANO1 channel (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Mus musculus)
Korea University

Curated by ChEMBL
LigandPNGBDBM50239432(CHEMBL4104747)
Affinity DataIC50:  1.53E+3nMAssay Description:Inhibition of GFP-fused mouse ANO1 channel expressed in HEK293A cells assessed as inhibition of ATP-induced channel current amplitude at membrane pot...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed