BDBM50239942 CHEMBL4081869::US9872852, Example 37

SMILES COc1cc(OCc2cccc(c2C)-c2ccccc2)cc(OC)c1CNCCNC(C)=O

InChI Key InChIKey=OYNIISWIMDFFAF-UHFFFAOYSA-N

Data  7 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50239942   

TargetProgrammed cell death 1 ligand 1(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50239942(CHEMBL4081869 | US9872852, Example 37)
Affinity DataIC50:  6nMAssay Description:Binding affinity to His-tagged PD-L1 (unknown origin) assessed as reduction in PD-L1/PD1-Ig interaction preincubated with PD-L1 for 15 mins followed ...More data for this Ligand-Target Pair
TargetProgrammed cell death 1 ligand 1(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50239942(CHEMBL4081869 | US9872852, Example 37)
Affinity DataKd: <1.00E+3nMAssay Description:Binding affinity to 15N-labeled human PD-L1 (18 to 134 residues) expressed in Escherichia coli BL21(DE3) by 1H-15N 2D HMQC NMR spectroscopic analysisMore data for this Ligand-Target Pair
TargetProgrammed cell death 1 ligand 1(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50239942(CHEMBL4081869 | US9872852, Example 37)
Affinity DataIC50:  53nMAssay Description:All binding studies were performed in an HTRF assay buffer consisting of dPBS supplemented with 0.1% (withv) bovine serum albumin and 0.05% (v/v) Twe...More data for this Ligand-Target Pair
TargetProgrammed cell death 1 ligand/protein 1(Homo sapiens)
Huaqiao University

Curated by ChEMBL
LigandPNGBDBM50239942(CHEMBL4081869 | US9872852, Example 37)
Affinity DataIC50: <100nMAssay Description:Inhibition of PD-1-Ig/His-PD-L1 (unknown origin) protein-protein interaction incubated with PD-L1 for 15 mins followed by addition of PD-1 for 15 min...More data for this Ligand-Target Pair
TargetProgrammed cell death 1 ligand 1(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50239942(CHEMBL4081869 | US9872852, Example 37)
Affinity DataIC50:  1nMAssay Description:Binding affinity to PDL1 (unknown origin) assessed as reduction in PDL1/PD1 protein-protein interaction preincubated for 15 mins followed by PD1 addi...More data for this Ligand-Target Pair
TargetProgrammed cell death 1 ligand/protein 1(Homo sapiens)
Huaqiao University

Curated by ChEMBL
LigandPNGBDBM50239942(CHEMBL4081869 | US9872852, Example 37)
Affinity DataIC50: <100nMAssay Description:Inhibition of human PD-1/PDL1 by HTRF assayMore data for this Ligand-Target Pair
TargetProgrammed cell death 1 ligand/protein 1(Homo sapiens)
Huaqiao University

Curated by ChEMBL
LigandPNGBDBM50239942(CHEMBL4081869 | US9872852, Example 37)
Affinity DataIC50:  83nMAssay Description:Inhibition of Tag2-PD-1/Tag1-PD-L1 (unknown origin) protein-protein interaction incubated for 15 mins by HTRF assayMore data for this Ligand-Target Pair
TargetProgrammed cell death 1 ligand 1(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50239942(CHEMBL4081869 | US9872852, Example 37)
Affinity DataIC50: <100nMAssay Description:Inhibition of PDL1 (unknown origin)More data for this Ligand-Target Pair