BDBM50240973 CHEMBL4102855

SMILES Nc1ncc(-c2nc(nc(n2)N2CCOCC2)N2CCOCC2)c(n1)C(F)(F)F

InChI Key InChIKey=IFPHRQQBRZZIOQ-UHFFFAOYSA-N

Data  2 KI  1 IC50  9 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50240973   

LigandPNGBDBM50240973(CHEMBL4102855)
Affinity DataKi:  8.10nMAssay Description:Inhibition of human N-terminal His6-tagged PI3K p110alpha/p85alpha expressed in baculovirus expression system after 1 hr using AlexaFluor647-labeled ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
University Of Basel

Curated by ChEMBL
LigandPNGBDBM50240973(CHEMBL4102855)
Affinity DataKi:  203nMAssay Description:Inhibition of human C-terminal GST-tagged mTOR (1360 to 2549 residues) expressed in baculovirus expression system using after 1 hr AlexaFluor647-labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta(Homo sapiens (Human))
University Of Basel

Curated by ChEMBL
LigandPNGBDBM50240973(CHEMBL4102855)
Affinity DataKd:  540nMAssay Description:In vitro renin inhibition was measured at pH 7.4 by using purified human kidney renin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
University Of Basel

Curated by ChEMBL
LigandPNGBDBM50240973(CHEMBL4102855)
Affinity DataKd:  130nMAssay Description:In vitro renin inhibition was measured at pH 7.4 by using purified human kidney renin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
University Of Basel

Curated by ChEMBL
LigandPNGBDBM50240973(CHEMBL4102855)
Affinity DataKd: >3.00E+4nMAssay Description:Inhibition of [3H]spiperone binding to rat striatal dopamine receptor D2 was determined in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
University Of Basel

Curated by ChEMBL
LigandPNGBDBM50240973(CHEMBL4102855)
Affinity DataKd:  1.20nMAssay Description:Binding affinity to human PI3Kalpha (R108 to N1068 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
University Of Basel

Curated by ChEMBL
LigandPNGBDBM50240973(CHEMBL4102855)
Affinity DataKd:  3.5nMAssay Description:Inhibition of [3H]spiperone binding to rat striatal dopamine receptor D2 was determined in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
University Of Basel

Curated by ChEMBL
LigandPNGBDBM50240973(CHEMBL4102855)
Affinity DataIC50:  312nMAssay Description:Inhibition of mTOR in human A2058 cells assessed as reduction in phosphorylation of S6 at ser235/236 residues after 1 hr by in-cell Western methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
University Of Basel

Curated by ChEMBL
LigandPNGBDBM50240973(CHEMBL4102855)
Affinity DataKd:  3.5nMAssay Description:Binding affinity to human PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
University Of Basel

Curated by ChEMBL
LigandPNGBDBM50240973(CHEMBL4102855)
Affinity DataKd:  61nMAssay Description:In vitro renin inhibition was measured at pH 7.4 by using purified human kidney renin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
University Of Basel

Curated by ChEMBL
LigandPNGBDBM50240973(CHEMBL4102855)
Affinity DataKd:  11nMAssay Description:Binding affinity to human PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
University Of Basel

Curated by ChEMBL
LigandPNGBDBM50240973(CHEMBL4102855)
Affinity DataKd:  2.70E+4nMAssay Description:Binding affinity to human PI4KCbeta (M1 to M828 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed