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BDBM50243316 ((2S,4R)-4-aminopyrrolidin-2-yl)(isoindolin-2-yl)methanone::CHEMBL452520

SMILES: N[C@H]1CN[C@@H](C1)C(=O)N1Cc2ccccc2C1

InChI Key: InChIKey=CBRFIYYAVQBBMO-NEPJUHHUSA-N

Data: 4 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50243316   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM50243316
PNG
(((2S,4R)-4-aminopyrrolidin-2-yl)(isoindolin-2-yl)m...)
Show SMILES N[C@H]1CN[C@@H](C1)C(=O)N1Cc2ccccc2C1
Show InChI InChI=1S/C13H17N3O/c14-11-5-12(15-6-11)13(17)16-7-9-3-1-2-4-10(9)8-16/h1-4,11-12,15H,5-8,14H2/t11-,12+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.40E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP8 (unknown origin)


Bioorg Med Chem Lett 18: 4159-62 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.079
BindingDB Entry DOI: 10.7270/Q2KS6RC4
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50243316
PNG
(((2S,4R)-4-aminopyrrolidin-2-yl)(isoindolin-2-yl)m...)
Show SMILES N[C@H]1CN[C@@H](C1)C(=O)N1Cc2ccccc2C1
Show InChI InChI=1S/C13H17N3O/c14-11-5-12(15-6-11)13(17)16-7-9-3-1-2-4-10(9)8-16/h1-4,11-12,15H,5-8,14H2/t11-,12+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.10E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP2 (unknown origin)


Bioorg Med Chem Lett 18: 4159-62 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.079
BindingDB Entry DOI: 10.7270/Q2KS6RC4
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM50243316
PNG
(((2S,4R)-4-aminopyrrolidin-2-yl)(isoindolin-2-yl)m...)
Show SMILES N[C@H]1CN[C@@H](C1)C(=O)N1Cc2ccccc2C1
Show InChI InChI=1S/C13H17N3O/c14-11-5-12(15-6-11)13(17)16-7-9-3-1-2-4-10(9)8-16/h1-4,11-12,15H,5-8,14H2/t11-,12+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.78E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP9 (unknown origin)


Bioorg Med Chem Lett 18: 4159-62 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.079
BindingDB Entry DOI: 10.7270/Q2KS6RC4
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50243316
PNG
(((2S,4R)-4-aminopyrrolidin-2-yl)(isoindolin-2-yl)m...)
Show SMILES N[C@H]1CN[C@@H](C1)C(=O)N1Cc2ccccc2C1
Show InChI InChI=1S/C13H17N3O/c14-11-5-12(15-6-11)13(17)16-7-9-3-1-2-4-10(9)8-16/h1-4,11-12,15H,5-8,14H2/t11-,12+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+5n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP4 (unknown origin)


Bioorg Med Chem Lett 18: 4159-62 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.079
BindingDB Entry DOI: 10.7270/Q2KS6RC4
More data for this
Ligand-Target Pair