BDBM50243700 4-(2-(4-(2-(trifluoromethyl)-1H-benzo[d]imidazol-4-yl)piperazin-1-yl)ethoxy)-1H-benzo[d]imidazole-2(3H)-thione::CHEMBL512893

SMILES FC(F)(F)c1nc2c(cccc2[nH]1)N1CCN(CCOc2cccc3[nH]c(=S)[nH]c23)CC1

InChI Key InChIKey=ZPFVOMYXTKCCLP-UHFFFAOYSA-N

Data  1 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50243700   

Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50243700(4-(2-(4-(2-(trifluoromethyl)-1H-benzo[d]imidazol-4...)
Affinity DataKi:  2.80nMAssay Description:Binding affinity to human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50243700(4-(2-(4-(2-(trifluoromethyl)-1H-benzo[d]imidazol-4...)
Affinity DataIC50:  790nMAssay Description:Displacement of [125I]-(D-Trp6)LHRH from human recombinant GnRH receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50243700(4-(2-(4-(2-(trifluoromethyl)-1H-benzo[d]imidazol-4...)
Affinity DataIC50:  7.60E+4nMAssay Description:Antagonist activity at recombinant GnRH receptor in CO2 asphyxiated rat primary pituitary cells assessed as reduction in (D-Trp6)LHRH-induced LH rele...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50243700(4-(2-(4-(2-(trifluoromethyl)-1H-benzo[d]imidazol-4...)
Affinity DataIC50:  4.50E+3nMAssay Description:Antagonist activity at human recombinant GnRH receptor assessed as reduction in (D-Trp6)LHRH-induced myo-(1,2)-[3H]inositol productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50243700(4-(2-(4-(2-(trifluoromethyl)-1H-benzo[d]imidazol-4...)
Affinity DataIC50:  800nMAssay Description:Binding affinity at human GnRH receptor by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50243700(4-(2-(4-(2-(trifluoromethyl)-1H-benzo[d]imidazol-4...)
Affinity DataIC50:  2.10E+4nMAssay Description:Displacement of [125I]-(D-Trp6)LHRH from rat recombinant GnRH receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed