BDBM50243880 3-(3,4,5-Trimethoxyphenyl)-4-(1-{[2-(trimethylsilyl)ethoxy]-methyl}-1H-indol-3-yl)-1,5-dihydro-2H-pyrrole-2-one::CHEMBL486437

SMILES COc1cc(cc(OC)c1OC)C1=C(CNC1=O)c1cn(COCC[Si](C)(C)C)c2ccccc12

InChI Key InChIKey=OBFNFWMFLWGMPB-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50243880   

TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243880(3-(3,4,5-Trimethoxyphenyl)-4-(1-{[2-(trimethylsily...)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of human recombinant VEGFR3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243880(3-(3,4,5-Trimethoxyphenyl)-4-(1-{[2-(trimethylsily...)
Affinity DataIC50:  2.20E+4nMAssay Description:Inhibition of human recombinant EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243880(3-(3,4,5-Trimethoxyphenyl)-4-(1-{[2-(trimethylsily...)
Affinity DataIC50:  4.40E+4nMAssay Description:Inhibition of human recombinant EPHB4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243880(3-(3,4,5-Trimethoxyphenyl)-4-(1-{[2-(trimethylsily...)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of human recombinant TIE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243880(3-(3,4,5-Trimethoxyphenyl)-4-(1-{[2-(trimethylsily...)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of human recombinant SRCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243880(3-(3,4,5-Trimethoxyphenyl)-4-(1-{[2-(trimethylsily...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of human recombinant VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243880(3-(3,4,5-Trimethoxyphenyl)-4-(1-{[2-(trimethylsily...)
Affinity DataIC50:  3.40E+4nMAssay Description:Inhibition of human recombinant FLT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50243880(3-(3,4,5-Trimethoxyphenyl)-4-(1-{[2-(trimethylsily...)
Affinity DataIC50:  8.70E+3nMAssay Description:Inhibition of human recombinant IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed