BDBM50244489 CHEMBL4095379

SMILES C[C@@H]1CN(C)CCN1c1ccc(Nc2cc(cn(C)c2=O)-c2cc(F)cc(N3CCn4c5CCCCc5cc4C3=O)c2CO)nc1

InChI Key InChIKey=LHAWBHQZJPVJOJ-JOCHJYFZSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50244489   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50244489(CHEMBL4095379)
Affinity DataKi:  0.370nMAssay Description:Inhibition of human recombinant C-terminal polyhistidine tagged BTK (1 to 659 residues)-mediated synthetic peptide substrate phosphorylation expresse...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50244489(CHEMBL4095379)
Affinity DataIC50:  17nMAssay Description:Inhibition of BTK in human whole blood-derived CD19+ B cells assessed as suppression of anti-IgM stimulated-CD69 expression preincubated for 1 hr fol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed