BDBM50246190 (R)-5-(4-(2-oxoazepan-3-ylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)indolin-2-one::CHEMBL488446

SMILES FC(F)(F)c1cnc(Nc2ccc3NC(=O)Cc3c2)nc1N[C@@H]1CCCCNC1=O

InChI Key InChIKey=OEVBGOMMLVZIHM-CQSZACIVSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50246190   

TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246190((R)-5-(4-(2-oxoazepan-3-ylamino)-5-(trifluoromethy...)
Affinity DataIC50:  49nMAssay Description:Inhibition of GST-tagged pyk2 (unknown origin) assessed as inhibition of poly-Glu-Tyr phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246190((R)-5-(4-(2-oxoazepan-3-ylamino)-5-(trifluoromethy...)
Affinity DataIC50:  300nMAssay Description:Inhibition of GST-tagged FAK (unknown origin) assessed as inhibition of poly-Glu-Tyr phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed