BDBM50246379 CHEMBL452342::N4-((1R,2R)-2-Dimethylamino-cyclopentyl)-N2-(2,2-dioxo-2,3-dihydro-1H-2lambda6-benzo[c]isothiazol-5-yl)-5-trifluoromethyl-pyrimidine-2,4-diamine

SMILES CN(C)[C@@H]1CCC[C@H]1Nc1nc(Nc2ccc3NS(=O)(=O)Cc3c2)ncc1C(F)(F)F

InChI Key InChIKey=XJSKDTYFOQQIKZ-HZPDHXFCSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50246379   

TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246379(CHEMBL452342 | N4-((1R,2R)-2-Dimethylamino-cyclope...)
Affinity DataIC50:  50nMAssay Description:Inhibition of GST-tagged pyk2 (unknown origin) assessed as inhibition of poly-Glu-Tyr phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246379(CHEMBL452342 | N4-((1R,2R)-2-Dimethylamino-cyclope...)
Affinity DataIC50: >650nMAssay Description:Inhibition of GST-tagged FAK (unknown origin) assessed as inhibition of poly-Glu-Tyr phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed