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BDBM50247599 (Z)-5-(4'-Hydroxybenzylidene)-2-thioxothiazolidin-4-one::5-(4-hydroxybenzylidene)-2-thioxothiazolidin-4-one::CHEMBL487697

SMILES: Oc1ccc(C=C2SC(S)=NC2=O)cc1

InChI Key: InChIKey=RAYIDZVPIAJJPF-UHFFFAOYSA-N

Data: 3 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50247599   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arylamine N-acetyltransferase 1


(Homo sapiens)
BDBM50247599
PNG
((Z)-5-(4'-Hydroxybenzylidene)-2-thioxothiazolidin-...)
Show SMILES Oc1ccc(C=C2SC(S)=NC2=O)cc1
Show InChI InChI=1S/C10H7NO2S2/c12-7-3-1-6(2-4-7)5-8-9(13)11-10(14)15-8/h1-5,12H,(H,11,13,14)
PDB
MMDB

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KEGG

UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.69E+4n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of human recombinant NAT1 assessed as hydrolysis of acetyl coA using PABA as substrate by Ellman's method


Bioorg Med Chem 17: 905-18 (2009)


Article DOI: 10.1016/j.bmc.2008.11.032
BindingDB Entry DOI: 10.7270/Q2PZ58Q3
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50247599
PNG
((Z)-5-(4'-Hydroxybenzylidene)-2-thioxothiazolidin-...)
Show SMILES Oc1ccc(C=C2SC(S)=NC2=O)cc1
Show InChI InChI=1S/C10H7NO2S2/c12-7-3-1-6(2-4-7)5-8-9(13)11-10(14)15-8/h1-5,12H,(H,11,13,14)
UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 1.01E+7n/an/an/an/an/an/a



Shaoyang University

Curated by ChEMBL


Assay Description
Inhibition of diphenolase activity of mushroom tyrosinase preincubated with compound for 10 mins before addition of L-DOPA as substrate by spectropho...


Bioorg Med Chem Lett 21: 2376-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.076
BindingDB Entry DOI: 10.7270/Q2SF2WG1
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50247599
PNG
((Z)-5-(4'-Hydroxybenzylidene)-2-thioxothiazolidin-...)
Show SMILES Oc1ccc(C=C2SC(S)=NC2=O)cc1
Show InChI InChI=1S/C10H7NO2S2/c12-7-3-1-6(2-4-7)5-8-9(13)11-10(14)15-8/h1-5,12H,(H,11,13,14)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.55E+3n/an/an/an/an/an/a



University of Messina

Curated by ChEMBL


Assay Description
Inhibition of bovine lens aldose reductase assessed as inhibition of NDAPH oxidation by non-linear regression analysis


Bioorg Med Chem Lett 21: 200-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.041
BindingDB Entry DOI: 10.7270/Q2ZP46C4
More data for this
Ligand-Target Pair