BDBM50247927 CHEMBL489706::N-hydroxy-3-(2-phenethyl-1-(pyridin-2-ylmethyl)-1H-benzo[d]imidazol-5-yl)acrylamide::US10201527, Compound 16::US10736881, Compound 16::US8551988, 16

SMILES ONC(=O)\C=C\c1ccc2n(Cc3ccccn3)c(CCc3ccccc3)nc2c1

InChI Key InChIKey=AIVHKZVAUIOORN-SDNWHVSQSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50247927   

TargetHistone deacetylase 8(Homo sapiens (Human))
Mei Pharma

US Patent
LigandPNGBDBM50247927(CHEMBL489706 | N-hydroxy-3-(2-phenethyl-1-(pyridin...)
Affinity DataIC50:  366nMAssay Description:The assay have been carried out in a 96 well format and the BIOMOL using a fluorescent-based HDAC activity assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Mei Pharma

US Patent
LigandPNGBDBM50247927(CHEMBL489706 | N-hydroxy-3-(2-phenethyl-1-(pyridin...)
Affinity DataIC50:  194nMAssay Description:The assay have been carried out in a 96 well format and the BIOMOL using a fluorescent-based HDAC activity assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Mei Pharma

US Patent
LigandPNGBDBM50247927(CHEMBL489706 | N-hydroxy-3-(2-phenethyl-1-(pyridin...)
Affinity DataIC50:  250nMAssay Description:Inhibition of recombinant HDAC1 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Mei Pharma

US Patent
LigandPNGBDBM50247927(CHEMBL489706 | N-hydroxy-3-(2-phenethyl-1-(pyridin...)
Affinity DataIC50:  366nMMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 8(Homo sapiens (Human))
Mei Pharma

US Patent
LigandPNGBDBM50247927(CHEMBL489706 | N-hydroxy-3-(2-phenethyl-1-(pyridin...)
Affinity DataIC50:  366nMAssay Description:To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5×105 cells/well for 24 h. Colo20...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Mei Pharma

US Patent
LigandPNGBDBM50247927(CHEMBL489706 | N-hydroxy-3-(2-phenethyl-1-(pyridin...)
Affinity DataIC50:  194nMAssay Description:The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Mei Pharma

US Patent
LigandPNGBDBM50247927(CHEMBL489706 | N-hydroxy-3-(2-phenethyl-1-(pyridin...)
Affinity DataIC50:  194nMAssay Description:The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...More data for this Ligand-Target Pair
In DepthDetails US Patent