BDBM50248510 CHEMBL489326::N-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

SMILES COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)c2cc1OC

InChI Key InChIKey=CKRJSIFFXMHDSE-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50248510   

TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50248510(CHEMBL489326 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  21nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50248510(CHEMBL489326 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  7nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50248510(CHEMBL489326 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  42nMAssay Description:Inhibition of AXL in human MDA-MB-231 cells assessed as receptor phosphorylation after 1 to 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50248510(CHEMBL489326 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant full length AXL using poly (Glu,Tyr) as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50248510(CHEMBL489326 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  7.80nMAssay Description:Inhibition of MET in human MDA-MB-231 cells assessed as receptor phosphorylation after 1 to 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50248510(CHEMBL489326 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  21nMAssay Description:Inhibition of GST-tagged c-Met expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50248510(CHEMBL489326 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human recombinant full length MET using poly (Glu,Tyr) as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50248510(CHEMBL489326 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  0.0350nMAssay Description:Inhibition of human recombinant full length VEGFR2 using poly (Glu,Tyr) as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50248510(CHEMBL489326 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human c-METMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50248510(CHEMBL489326 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  21nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50248510(CHEMBL489326 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of VEGFR2 in human MDA-MB-231 cells assessed as receptor phosphorylation after 1 to 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed