BDBM50249319 2-(2-aminoethylamino)-4-(3-(trifluoromethyl)phenylamino)pyrimidine-5-carboxamide::CHEMBL471901

SMILES NCCNc1ncc(C(N)=O)c(Nc2cccc(c2)C(F)(F)F)n1

InChI Key InChIKey=FQNFLNSVHWCZML-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50249319   

TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50249319(2-(2-aminoethylamino)-4-(3-(trifluoromethyl)phenyl...)
Affinity DataIC50:  1.12E+4nMAssay Description:Inhibition of human ZAP70More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine--tRNA ligase(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50249319(2-(2-aminoethylamino)-4-(3-(trifluoromethyl)phenyl...)
Affinity DataIC50:  41nMAssay Description:Inhibition of human SykMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249319(2-(2-aminoethylamino)-4-(3-(trifluoromethyl)phenyl...)
Affinity DataIC50:  41nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249319(2-(2-aminoethylamino)-4-(3-(trifluoromethyl)phenyl...)
Affinity DataIC50:  41nMAssay Description:Inhibition of recombinant Syk (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249319(2-(2-aminoethylamino)-4-(3-(trifluoromethyl)phenyl...)
Affinity DataIC50:  41nMAssay Description:Inhibition of spleen tyrosine kinase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249319(2-(2-aminoethylamino)-4-(3-(trifluoromethyl)phenyl...)
Affinity DataIC50:  41nMAssay Description:Inhibition of p72 SykChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type 1D(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50249319(2-(2-aminoethylamino)-4-(3-(trifluoromethyl)phenyl...)
Affinity DataIC50:  432nMAssay Description:Inhibition of recombinant human full-length His-tagged CAMK1D expressed in baculovirus expression system using autocamtide-2 as substrate preincubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50249319(2-(2-aminoethylamino)-4-(3-(trifluoromethyl)phenyl...)
Affinity DataIC50:  1.12E+4nMAssay Description:Inhibition of ZAP70Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50249319(2-(2-aminoethylamino)-4-(3-(trifluoromethyl)phenyl...)
Affinity DataIC50:  2.26E+4nMAssay Description:Inhibition of ItkChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50249319(2-(2-aminoethylamino)-4-(3-(trifluoromethyl)phenyl...)
Affinity DataIC50:  1.55E+4nMAssay Description:Inhibition of BtkChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type 1D(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50249319(2-(2-aminoethylamino)-4-(3-(trifluoromethyl)phenyl...)
Affinity DataIC50:  456nMAssay Description:Inhibition of human CAMK1D using KKALRRQETVDAL as substrate in presence of [gamma-33P]-ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249319(2-(2-aminoethylamino)-4-(3-(trifluoromethyl)phenyl...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human SYK using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma-33P]-ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C epsilon type(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50249319(2-(2-aminoethylamino)-4-(3-(trifluoromethyl)phenyl...)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibition of PKCepsilonChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed