BDBM50250910 CHEMBL4072630::US10696655, Example 18::US11168070, Example 18

SMILES Cn1cc(cn1)-c1cc2CCCN(c3ccc4n(C)c(=O)n(C)c4c3)c2cc1C(F)F

InChI Key InChIKey=QZTRJRAVSCCLRR-UHFFFAOYSA-N

Data  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50250910   

TargetBromodomain-containing protein 4(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50250910(CHEMBL4072630 | US10696655, Example 18 | US1116807...)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of His tagged recombinant BRD4 bromodomain 1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCREB-binding protein(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50250910(CHEMBL4072630 | US10696655, Example 18 | US1116807...)
Affinity DataIC50:  20nMAssay Description:Inhibition of His tagged recombinant CBP (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCREB-binding protein(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50250910(CHEMBL4072630 | US10696655, Example 18 | US1116807...)
Affinity DataIC50:  19nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCREB-binding protein(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50250910(CHEMBL4072630 | US10696655, Example 18 | US1116807...)
Affinity DataIC50:  19nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCREB-binding protein/Histone acetyltransferase p300(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50250910(CHEMBL4072630 | US10696655, Example 18 | US1116807...)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of P300/CBP in human MV4-11 cells assessed as reduction in MYC expression after 4 hrs by luminescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed