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BDBM50251633 (+/-)-2-(2,6-diethylphenyl)-N-(2,5-dimethoxyphenyl)-4-methoxy-N-methyl-5,6,7,8-tetrahydroquinolin-5-amine::CHEMBL479554

SMILES: CCc1cccc(CC)c1-c1cc(OC)c2C(CCCc2n1)N(C)c1cc(OC)ccc1OC

InChI Key: InChIKey=UJBUFRAPYKPGDO-UHFFFAOYNA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50251633   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50251633
PNG
((+/-)-2-(2,6-diethylphenyl)-N-(2,5-dimethoxyphenyl...)
Show SMILES CCc1cccc(CC)c1-c1cc(OC)c2C(CCCc2n1)N(C)c1cc(OC)ccc1OC
Show InChI InChI=1/C29H36N2O3/c1-7-19-11-9-12-20(8-2)28(19)23-18-27(34-6)29-22(30-23)13-10-14-24(29)31(3)25-17-21(32-4)15-16-26(25)33-5/h9,11-12,15-18,24H,7-8,10,13-14H2,1-6H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.60E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant C5a receptor in U937 cells assessed as inhibition of C5a-induced calcium mobilization by FLIPR assay


Bioorg Med Chem Lett 18: 3852-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.059
BindingDB Entry DOI: 10.7270/Q2765F4X
More data for this
Ligand-Target Pair