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BDBM50251634 (+/-)-N-(2-chloro-5-methoxyphenyl)-2-(2,6-diethylphenyl)-4-methoxy-N-methyl-5,6,7,8-tetrahydroquinolin-5-amine::CHEMBL480128

SMILES: CCc1cccc(CC)c1-c1cc(OC)c2C(CCCc2n1)N(C)c1cc(OC)ccc1Cl

InChI Key: InChIKey=OCFYSUBUVGRBOV-UHFFFAOYNA-N

Data: 1 IC50

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50251634   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50251634
PNG
((+/-)-N-(2-chloro-5-methoxyphenyl)-2-(2,6-diethylp...)
Show SMILES CCc1cccc(CC)c1-c1cc(OC)c2C(CCCc2n1)N(C)c1cc(OC)ccc1Cl
Show InChI InChI=1/C28H33ClN2O2/c1-6-18-10-8-11-19(7-2)27(18)23-17-26(33-5)28-22(30-23)12-9-13-24(28)31(3)25-16-20(32-4)14-15-21(25)29/h8,10-11,14-17,24H,6-7,9,12-13H2,1-5H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 950n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant C5a receptor in U937 cells assessed as inhibition of C5a-induced calcium mobilization by FLIPR assay


Bioorg Med Chem Lett 18: 3852-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.059
BindingDB Entry DOI: 10.7270/Q2765F4X
More data for this
Ligand-Target Pair