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BDBM50251635 (+/-)-2-(2,6-dimethylphenyl)-4-methoxy-N-(5-methoxy-2-methylphenyl)-N-methyl-5,6,7,8-tetrahydroquinolin-5-amine::CHEMBL480318

SMILES: COc1ccc(C)c(c1)N(C)C1CCCc2nc(cc(OC)c12)-c1c(C)cccc1C

InChI Key: InChIKey=NQEQEBYWTDYCLN-UHFFFAOYSA-N

Data: 1 IC50

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50251635   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50251635
PNG
((+/-)-2-(2,6-dimethylphenyl)-4-methoxy-N-(5-methox...)
Show SMILES COc1ccc(C)c(c1)N(C)C1CCCc2nc(cc(OC)c12)-c1c(C)cccc1C
Show InChI InChI=1S/C27H32N2O2/c1-17-13-14-20(30-5)15-24(17)29(4)23-12-8-11-21-27(23)25(31-6)16-22(28-21)26-18(2)9-7-10-19(26)3/h7,9-10,13-16,23H,8,11-12H2,1-6H3
PDB

KEGG

UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 3.20E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant C5a receptor in U937 cells assessed as inhibition of C5a-induced calcium mobilization by FLIPR assay


Bioorg Med Chem Lett 18: 3852-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.059
BindingDB Entry DOI: 10.7270/Q2765F4X
More data for this
Ligand-Target Pair