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BDBM50251675 2-(2,6-diethylphenyl)-4-methoxy-N-(3-methoxyphenyl)-5,6,7,8-tetrahydroquinolin-5-amine::CHEMBL517693

SMILES: CCc1cccc(CC)c1-c1cc(OC)c2C(CCCc2n1)Nc1cccc(OC)c1

InChI Key: InChIKey=SFCUYXXFEDZGAP-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50251675   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50251675
PNG
(2-(2,6-diethylphenyl)-4-methoxy-N-(3-methoxyphenyl...)
Show SMILES CCc1cccc(CC)c1-c1cc(OC)c2C(CCCc2n1)Nc1cccc(OC)c1
Show InChI InChI=1S/C27H32N2O2/c1-5-18-10-7-11-19(6-2)26(18)24-17-25(31-4)27-22(14-9-15-23(27)29-24)28-20-12-8-13-21(16-20)30-3/h7-8,10-13,16-17,22,28H,5-6,9,14-15H2,1-4H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 7.40E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant C5a receptor in U937 cells assessed as inhibition of C5a-induced calcium mobilization by FLIPR assay


Bioorg Med Chem Lett 18: 3852-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.059
BindingDB Entry DOI: 10.7270/Q2765F4X
More data for this
Ligand-Target Pair