BDBM50252324 CHEMBL4100138

SMILES C(COc1ccc2nc(oc2c1)-c1cccc(NC2CCN(Cc3ccccc3)CC2)c1)CN1CCCC1

InChI Key InChIKey=MZXYYKFMCJEETH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50252324   

TargetToll-like receptor 7(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50252324(CHEMBL4100138)
Affinity DataIC50:  8.09E+3nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of CL264-induced NF-kappaB activation after 24 hrs by spectrophoto...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 9(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50252324(CHEMBL4100138)
Affinity DataIC50:  100nMAssay Description:Antagonist activity at TLR9 in human plasmacytoid dendritic cells assessed as inhibition of CpGA-induced IFN-alpha production after 18 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 9(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50252324(CHEMBL4100138)
Affinity DataIC50:  130nMAssay Description:Antagonist activity at human TLR9 expressed in HEK293 cells assessed as inhibition of CpGB-induced NF-kappaB activation after 24 hrs by spectrophotom...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 9(Homo sapiens (Human))
Csir-Indian Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50252324(CHEMBL4100138)
Affinity DataIC50:  100nMAssay Description:Antagonist activity at TLR9 in human plasmacytoid dendritic cells assessed as inhibition of CpGA-induced IFN-alpha production after 18 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed