BDBM50255529 Ac-Lys(CoA)-NH2::CHEMBL505121

SMILES CC(=O)N[C@@H](CCCCNC(=O)CSCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)n1cnc2c(N)ncnc12)C(N)=O

InChI Key InChIKey=YGZKIOPJGFQDSR-QGSWMBNESA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50255529   

TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50255529(Ac-Lys(CoA)-NH2 | CHEMBL505121)
Affinity DataIC50:  2.00E+5nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PCAF expressed in baculovirus expression system using histone substrate incubated for 10 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50255529(Ac-Lys(CoA)-NH2 | CHEMBL505121)
Affinity DataIC50:  500nMAssay Description:Inhibition of full length recombinant human FLAG-tagged p300 expressed in baculovirus expression system using histone substrate incubated for 10 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50255529(Ac-Lys(CoA)-NH2 | CHEMBL505121)
Affinity DataIC50:  50nMAssay Description:Inhibition of recombinant full length p300 (unknown origin) using N-terminal H4-20 peptide substrate incubated for 7 mins by radiometric gel assay in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50255529(Ac-Lys(CoA)-NH2 | CHEMBL505121)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human recombinant C-terminal GST-tagged p300 (1195 to 1673 residues) expressed in competent Escherichia coli DH5alpha cells using histo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT5(Homo sapiens (Human))
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50255529(Ac-Lys(CoA)-NH2 | CHEMBL505121)
Affinity DataIC50:  2.98E+4nMAssay Description:Inhibition of recombinant Tip60 (1-513) expressed in Escherichia coli BL21 (DE3) by liquid scintillationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50255529(Ac-Lys(CoA)-NH2 | CHEMBL505121)
Affinity DataIC50:  500nMAssay Description:Inhibition of recombinant p300 (unknown origin) using mixed histones and acetyl-coA as substrates incubated for 10 minsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50255529(Ac-Lys(CoA)-NH2 | CHEMBL505121)
Affinity DataIC50:  1.08E+5nMAssay Description:Inhibition of PCAF HAT domain (493-658) expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50255529(Ac-Lys(CoA)-NH2 | CHEMBL505121)
Affinity DataIC50:  500nMAssay Description:Inhibition of recombinant FLAG-tagged human P300 expressed in Baculovirus expression system using histone peptide as substrate after 10 mins in prese...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50255529(Ac-Lys(CoA)-NH2 | CHEMBL505121)
Affinity DataIC50:  500nMAssay Description:Inhibition of recombinant human p300 using [14C]acetyl-CoA as substrate measured after 10 mins by phosphor imaging analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50255529(Ac-Lys(CoA)-NH2 | CHEMBL505121)
Affinity DataIC50:  500nMAssay Description:Inhibition of N-terminal His-tagged human recombinant p300 catalytic domain (1284-1673 residues) using histone H4-8 peptide and [14C]acetyl CoA as su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50255529(Ac-Lys(CoA)-NH2 | CHEMBL505121)
Affinity DataIC50:  980nMAssay Description:Inhibition of recombinant p300More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed