BDBM50257080 CHEMBL4096818
SMILES Cc1cc(Oc2cncc(Cl)c2)cc(n1)C(=O)Nc1ccc(F)cn1
InChI Key InChIKey=CEIBXTSWBBWOPN-UHFFFAOYSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50257080
TargetCytochrome P450 2D6(Homo sapiens (Human))
Vanderbilt University Institute Of Imaging Science
Curated by ChEMBL
Vanderbilt University Institute Of Imaging Science
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 5 mins followed by NADPH addition measured after ...More data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Vanderbilt University Institute Of Imaging Science
Curated by ChEMBL
Vanderbilt University Institute Of Imaging Science
Curated by ChEMBL
Affinity DataIC50: 2.15E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 5 mins followed by NADPH addition measured after 8 mins...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science
Curated by ChEMBL
Vanderbilt University Institute Of Imaging Science
Curated by ChEMBL
Affinity DataIC50: 7.20nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science
Curated by ChEMBL
Vanderbilt University Institute Of Imaging Science
Curated by ChEMBL
Affinity DataIC50: 7.20nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Vanderbilt University Institute Of Imaging Science
Curated by ChEMBL
Vanderbilt University Institute Of Imaging Science
Curated by ChEMBL
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 5 mins followed by NADPH addition measured after 8 mins ...More data for this Ligand-Target Pair
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vanderbilt University Institute Of Imaging Science
Curated by ChEMBL
Vanderbilt University Institute Of Imaging Science
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using tacrine as substrate preincubated for 5 mins followed by NADPH addition measured after 8 mins by...More data for this Ligand-Target Pair