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BDBM50257580 3-(3-chloro-4-fluorophenyl)-2-(pyridin-4-yl)-1H-pyrrolo[3,2-b]pyridine-5-carbonitrile::CHEMBL521639

SMILES: Fc1ccc(cc1Cl)-c1c([nH]c2ccc(nc12)C#N)-c1ccncc1

InChI Key: InChIKey=VZTBOCWTRFEYTA-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50257580   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50257580
PNG
(3-(3-chloro-4-fluorophenyl)-2-(pyridin-4-yl)-1H-py...)
Show SMILES Fc1ccc(cc1Cl)-c1c([nH]c2ccc(nc12)C#N)-c1ccncc1
Show InChI InChI=1S/C19H10ClFN4/c20-14-9-12(1-3-15(14)21)17-18(11-5-7-23-8-6-11)25-16-4-2-13(10-22)24-19(16)17/h1-9,25H
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 180n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50257580
PNG
(3-(3-chloro-4-fluorophenyl)-2-(pyridin-4-yl)-1H-py...)
Show SMILES Fc1ccc(cc1Cl)-c1c([nH]c2ccc(nc12)C#N)-c1ccncc1
Show InChI InChI=1S/C19H10ClFN4/c20-14-9-12(1-3-15(14)21)17-18(11-5-7-23-8-6-11)25-16-4-2-13(10-22)24-19(16)17/h1-9,25H
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 180n/an/an/an/an/an/a



Technical University of Darmstadt

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human c-Met expressed in SF9 cells


Bioorg Med Chem Lett 19: 1879-82 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.069
BindingDB Entry DOI: 10.7270/Q2BK1C66
More data for this
Ligand-Target Pair