BDBM50257621 7-(4-(2-chlorophenoxy)piperidin-1-ylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine::CHEMBL492301

SMILES Clc1ccccc1OC1CCN(CC1)S(=O)(=O)c1ccc2CCNCCc2c1

InChI Key InChIKey=ZVFFUTQAERXNNF-UHFFFAOYSA-N

Data  2 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50257621   

Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257621(7-(4-(2-chlorophenoxy)piperidin-1-ylsulfonyl)-2,3,...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]mesulergine form human recombinant 5HT2C receptor expressed in mouse Swiss 3T3 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257621(7-(4-(2-chlorophenoxy)piperidin-1-ylsulfonyl)-2,3,...)
Affinity DataKi:  2.90E+3nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257621(7-(4-(2-chlorophenoxy)piperidin-1-ylsulfonyl)-2,3,...)
Affinity DataEC50:  31nMAssay Description:Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257621(7-(4-(2-chlorophenoxy)piperidin-1-ylsulfonyl)-2,3,...)
Affinity DataEC50: >9.94E+3nMAssay Description:Agonist activity at human recombinant 5HT2B receptor by cell-based systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257621(7-(4-(2-chlorophenoxy)piperidin-1-ylsulfonyl)-2,3,...)
Affinity DataEC50:  32nMAssay Description:Agonist activity at human 5HT2A receptor expressed in mouse Swiss 3T3 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed