BDBM50259376 3-((R)-1-Phenyl-ethylamino)-4-(pyridin-4-ylamino)-cyclobut-3-ene-1,2-dione::3-{[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione::CHEMBL466496

SMILES C[C@@H](Nc1c(Nc2ccncc2)c(=O)c1=O)c1ccccc1

InChI Key InChIKey=MCBPNFWHHNJTGN-LLVKDONJSA-N

Data  16 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50259376   

TargetAurora kinase B(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259376(3-((R)-1-Phenyl-ethylamino)-4-(pyridin-4-ylamino)-...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform alpha(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50259376(3-((R)-1-Phenyl-ethylamino)-4-(pyridin-4-ylamino)-...)
Affinity DataIC50:  250nMAssay Description:Inhibition of CK1 using KRRRALS(p)VASLPGL as substrate after 40 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259376(3-((R)-1-Phenyl-ethylamino)-4-(pyridin-4-ylamino)-...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of PKCalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259376(3-((R)-1-Phenyl-ethylamino)-4-(pyridin-4-ylamino)-...)
Affinity DataIC50:  810nMAssay Description:Inhibition of RSK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259376(3-((R)-1-Phenyl-ethylamino)-4-(pyridin-4-ylamino)-...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform gamma-1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259376(3-((R)-1-Phenyl-ethylamino)-4-(pyridin-4-ylamino)-...)
Affinity DataIC50:  250nMAssay Description:Inhibition of CK1-gamma1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259376(3-((R)-1-Phenyl-ethylamino)-4-(pyridin-4-ylamino)-...)
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibition of ERK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fyn(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259376(3-((R)-1-Phenyl-ethylamino)-4-(pyridin-4-ylamino)-...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of FYN (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259376(3-((R)-1-Phenyl-ethylamino)-4-(pyridin-4-ylamino)-...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259376(3-((R)-1-Phenyl-ethylamino)-4-(pyridin-4-ylamino)-...)
Affinity DataIC50:  4.05E+4nMAssay Description:Inhibition of PDGFRalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259376(3-((R)-1-Phenyl-ethylamino)-4-(pyridin-4-ylamino)-...)
Affinity DataIC50:  60nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259376(3-((R)-1-Phenyl-ethylamino)-4-(pyridin-4-ylamino)-...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259376(3-((R)-1-Phenyl-ethylamino)-4-(pyridin-4-ylamino)-...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259376(3-((R)-1-Phenyl-ethylamino)-4-(pyridin-4-ylamino)-...)
Affinity DataIC50:  600nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259376(3-((R)-1-Phenyl-ethylamino)-4-(pyridin-4-ylamino)-...)
Affinity DataIC50:  8.90E+3nMAssay Description:Inhibition of human recombinant MK2More data for this Ligand-Target Pair
LigandPNGBDBM50259376(3-((R)-1-Phenyl-ethylamino)-4-(pyridin-4-ylamino)-...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of IKKalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed