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BDBM50260826 CHEMBL497761::N-hydroxy-2,3-bis(4-methoxyphenylsulfonamido)propanamide

SMILES: COc1ccc(cc1)S(=O)(=O)NCC(NS(=O)(=O)c1ccc(OC)cc1)C(=O)NO

InChI Key: InChIKey=ZUAZPXLMAVHRDA-UHFFFAOYSA-N

Data: 3 KI

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50260826   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Collagenase


(Homo sapiens (Human))
BDBM50260826
PNG
(CHEMBL497761 | N-hydroxy-2,3-bis(4-methoxyphenylsu...)
Show SMILES COc1ccc(cc1)S(=O)(=O)NCC(NS(=O)(=O)c1ccc(OC)cc1)C(=O)NO
Show InChI InChI=1S/C17H21N3O8S2/c1-27-12-3-7-14(8-4-12)29(23,24)18-11-16(17(21)19-22)20-30(25,26)15-9-5-13(28-2)6-10-15/h3-10,16,18,20,22H,11H2,1-2H3,(H,19,21)
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PC sid
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Article
PubMed
39n/an/an/an/an/an/an/an/a



North Dakota State University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP9


Bioorg Med Chem Lett 18: 3333-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.035
BindingDB Entry DOI: 10.7270/Q2SX6D1R
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50260826
PNG
(CHEMBL497761 | N-hydroxy-2,3-bis(4-methoxyphenylsu...)
Show SMILES COc1ccc(cc1)S(=O)(=O)NCC(NS(=O)(=O)c1ccc(OC)cc1)C(=O)NO
Show InChI InChI=1S/C17H21N3O8S2/c1-27-12-3-7-14(8-4-12)29(23,24)18-11-16(17(21)19-22)20-30(25,26)15-9-5-13(28-2)6-10-15/h3-10,16,18,20,22H,11H2,1-2H3,(H,19,21)
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PC sid
UniChem

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Article
PubMed
335n/an/an/an/an/an/an/an/a



North Dakota State University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP10


Bioorg Med Chem Lett 18: 3333-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.035
BindingDB Entry DOI: 10.7270/Q2SX6D1R
More data for this
Ligand-Target Pair
Matrix metalloproteinase-7 (MMP7)


(Homo sapiens (Human))
BDBM50260826
PNG
(CHEMBL497761 | N-hydroxy-2,3-bis(4-methoxyphenylsu...)
Show SMILES COc1ccc(cc1)S(=O)(=O)NCC(NS(=O)(=O)c1ccc(OC)cc1)C(=O)NO
Show InChI InChI=1S/C17H21N3O8S2/c1-27-12-3-7-14(8-4-12)29(23,24)18-11-16(17(21)19-22)20-30(25,26)15-9-5-13(28-2)6-10-15/h3-10,16,18,20,22H,11H2,1-2H3,(H,19,21)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
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PC cid
PC sid
UniChem

Patents


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Article
PubMed
605n/an/an/an/an/an/an/an/a



North Dakota State University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP7


Bioorg Med Chem Lett 18: 3333-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.035
BindingDB Entry DOI: 10.7270/Q2SX6D1R
More data for this
Ligand-Target Pair