BDBM50260880 3-(3-Chloro-biphenyl-4-yl)-5-[1-(4-chloro-phenyl)-cyclobutyl]-4-methyl-4H-[1,2,4]triazole::CHEMBL494638

SMILES Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1Cl)-c1ccccc1

InChI Key InChIKey=DLCWGHYEPISYHV-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50260880   

Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50260880(3-(3-Chloro-biphenyl-4-yl)-5-[1-(4-chloro-phenyl)-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human 11beta HSD1 by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50260880(3-(3-Chloro-biphenyl-4-yl)-5-[1-(4-chloro-phenyl)-...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of mouse 11beta HSD1 by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))TBA
LigandPNGBDBM50260880(3-(3-Chloro-biphenyl-4-yl)-5-[1-(4-chloro-phenyl)-...)
Affinity DataEC50:  1.70E+3nMMore data for this Ligand-Target Pair
In DepthDetails
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50260880(3-(3-Chloro-biphenyl-4-yl)-5-[1-(4-chloro-phenyl)-...)
Affinity DataIC50:  1nMMore data for this Ligand-Target Pair
In DepthDetails
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))TBA
LigandPNGBDBM50260880(3-(3-Chloro-biphenyl-4-yl)-5-[1-(4-chloro-phenyl)-...)
Affinity DataEC50:  1.70E+3nMAssay Description:Agonist activity at human PXRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed