BDBM50264772 3-Hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic acid ([1,1';4',1'']terphenyl-4-ylmethyl)-amide::AM-6::CHEMBL489603

SMILES Cc1cc(=O)c(O)c(o1)C(=O)NCc1ccc(cc1)-c1ccc(cc1)-c1ccccc1

InChI Key InChIKey=HDDDAEIHJFNBGK-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50264772   

Target72 kDa type IV collagenase(Homo sapiens (Human))
University of California San Diego

LigandPNGBDBM50264772(3-Hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic aci...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition assay using matrix metalloproteinases.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50264772(3-Hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic aci...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of human MMP-14 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr followed by susbstrate addition by fluorescen...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetStromelysin-1(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50264772(3-Hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic aci...)
Affinity DataIC50:  19nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
University of California San Diego

LigandPNGBDBM50264772(3-Hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic aci...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50264772(3-Hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic aci...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50264772(3-Hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic aci...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human MMP-1 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr followed by susbstrate addition by fluorescent...More data for this Ligand-Target Pair
In DepthDetails PubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
University of California San Diego

LigandPNGBDBM50264772(3-Hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic aci...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of human MMP-2 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr followed by susbstrate addition by fluorescent...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetStromelysin-1(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50264772(3-Hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic aci...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human MMP-3 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr followed by susbstrate addition by fluorescent...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMatrilysin(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50264772(3-Hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic aci...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human MMP-7 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr followed by susbstrate addition by fluorescent...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50264772(3-Hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic aci...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of human MMP-8 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr followed by susbstrate addition by fluorescent...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50264772(3-Hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic aci...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human MMP-9 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr followed by susbstrate addition by fluorescent...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetStromelysin-2(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50264772(3-Hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic aci...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human MMP-10 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr followed by susbstrate addition by fluorescen...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50264772(3-Hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic aci...)
Affinity DataIC50:  177nMAssay Description:Inhibition of human MMP-12 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr followed by susbstrate addition by fluorescen...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCollagenase 3(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50264772(3-Hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic aci...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human MMP-13 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr followed by susbstrate addition by fluorescen...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetStromelysin-1(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50264772(3-Hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic aci...)
Affinity DataIC50:  19nMAssay Description:Inhibition assay using matrix metalloproteinases.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed