BDBM50264832 2,6-bis(4-hydroxybenzylidene)cyclohexanone::CHEMBL482409

SMILES Oc1ccc(\C=C2/CCC\C(=C/c3ccc(O)cc3)C2=O)cc1

InChI Key InChIKey=MGXGEFQCJBBKND-UNZYHPAISA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50264832   

Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Wenzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50264832(2,6-bis(4-hydroxybenzylidene)cyclohexanone | CHEMB...)
Affinity DataIC50:  1.94E+3nMAssay Description:Inhibition of 11beta-HSD1 in human liver microsomes using [3H]-cortisone as substrate assessed as formation of cortisol after 60 to 90 mins by radiom...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Wenzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50264832(2,6-bis(4-hydroxybenzylidene)cyclohexanone | CHEMB...)
Affinity DataIC50:  633nMAssay Description:Inhibition of 11beta-HSD1 in Sprague-Dawley rat leydig cells at 100 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Wenzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50264832(2,6-bis(4-hydroxybenzylidene)cyclohexanone | CHEMB...)
Affinity DataIC50:  195nMAssay Description:Inhibition of human 11beta-HSD1 transfected in CHOP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue factor(Homo sapiens (Human))TBA
LigandPNGBDBM50264832(2,6-bis(4-hydroxybenzylidene)cyclohexanone | CHEMB...)
Affinity DataIC50:  0.940nMAssay Description:Inhibition of tissue factor in Homo sapiens (human) THP1-cells using factor 10a chromogenic substrate assessed as inhibition of LPS-iduced procoagula...More data for this Ligand-Target Pair
In DepthDetails Article
TargetCytochrome P450 2C9(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50264832(2,6-bis(4-hydroxybenzylidene)cyclohexanone | CHEMB...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human recombinant CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
Universiti Putra Malaysia

Curated by ChEMBL
LigandPNGBDBM50264832(2,6-bis(4-hydroxybenzylidene)cyclohexanone | CHEMB...)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of tyrosinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50264832(2,6-bis(4-hydroxybenzylidene)cyclohexanone | CHEMB...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human recombinant CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed