BDBM50266537 CHEMBL4075688::US10323016, Example 3

SMILES COc1ccc(cc1OC)N(C)c1cnc(SCc2ccccc2F)n1-c1ccc(F)cc1

InChI Key InChIKey=FGPFAMGSKPYXBQ-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50266537   

TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Universite De Lille 2 Droit Et Sante

US Patent
LigandPNGBDBM50266537(CHEMBL4075688 | US10323016, Example 3)
Affinity DataEC50:  128nMAssay Description:In the following tables TGR5 activation by compounds and subsequent increase in intracellular cAMP were evaluated using a luciferase reporter gene as...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Universite De Lille 2 Droit Et Sante

US Patent
LigandPNGBDBM50266537(CHEMBL4075688 | US10323016, Example 3)
Affinity DataEC50:  128nMAssay Description:Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50266537(CHEMBL4075688 | US10323016, Example 3)
Affinity DataEC50:  12nMAssay Description:Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50266537(CHEMBL4075688 | US10323016, Example 3)
Affinity DataEC50:  12nMAssay Description:In the following tables TGR5 activation by compounds and subsequent increase in intracellular cAMP were evaluated using a luciferase reporter gene as...More data for this Ligand-Target Pair
In DepthDetails US Patent