BDBM50266575 CHEMBL4085777::US10323016, Example 14

SMILES COc1ccc(cc1)-n1c(SCc2c(F)cccc2F)ncc1N(C)c1ccc(OC)c(OC)c1

InChI Key InChIKey=JCKNYVPCZLTWCY-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50266575   

TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Universite De Lille 2 Droit Et Sante

US Patent
LigandPNGBDBM50266575(CHEMBL4085777 | US10323016, Example 14)
Affinity DataEC50:  7.70E+3nMAssay Description:In the following tables TGR5 activation by compounds and subsequent increase in intracellular cAMP were evaluated using a luciferase reporter gene as...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50266575(CHEMBL4085777 | US10323016, Example 14)
Affinity DataEC50:  939nMAssay Description:Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Universite De Lille 2 Droit Et Sante

US Patent
LigandPNGBDBM50266575(CHEMBL4085777 | US10323016, Example 14)
Affinity DataEC50:  7.75E+3nMAssay Description:Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50266575(CHEMBL4085777 | US10323016, Example 14)
Affinity DataEC50:  940nMAssay Description:In the following tables TGR5 activation by compounds and subsequent increase in intracellular cAMP were evaluated using a luciferase reporter gene as...More data for this Ligand-Target Pair
In DepthDetails US Patent