BDBM50266968 CHEMBL4065619::US11773085, Compound B27

SMILES CC(=O)c1cc(-c2cc(ccc2C)C(=O)NC2CC2)c2ncccn12

InChI Key InChIKey=RPBMXJHQYJLPDN-UHFFFAOYSA-N

Data  1 IC50  8 Kd

PDB links: 4 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50266968   

TargetBromodomain-containing protein 9(Homo sapiens (Human))
H. Lee Moffitt Cancer Center And Research Institute

Curated by ChEMBL
LigandPNGBDBM50266968(CHEMBL4065619 | US11773085, Compound B27)
Affinity DataKd:  33nMAssay Description:Binding affinity to BRD9 (unknown origin) by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 7(Homo sapiens (Human))
H. Lee Moffitt Cancer Center And Research Institute

Curated by ChEMBL
LigandPNGBDBM50266968(CHEMBL4065619 | US11773085, Compound B27)
Affinity DataKd:  340nMAssay Description:Binding affinity to BRD7 (unknown origin) by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 7(Homo sapiens (Human))
H. Lee Moffitt Cancer Center And Research Institute

Curated by ChEMBL
LigandPNGBDBM50266968(CHEMBL4065619 | US11773085, Compound B27)
Affinity DataKd:  556nMAssay Description:Binding affinity to recombinant human His-tagged BRD7 (129 to 250 residues) expressed in Escherichia coli BL21 DE3 assessed as dissociation constant ...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM50266968(CHEMBL4065619 | US11773085, Compound B27)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to BRD4 BD1 (unknown origin) assessed as dissociation constant by SYPRO orange dye based differential scanning fluorimetryMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 9 [133-239](Homo sapiens (Human))
Foghorn Therapeutics

US Patent
LigandPNGBDBM50266968(CHEMBL4065619 | US11773085, Compound B27)
Affinity DataIC50:  550nMAssay Description:A mixture of biotinylated-ligand and SureLight Allophycocyanin-Streptavidin (APC-SA, PerkinElmer AD0201) in 50 mM HEPES (pH 7.4), 50 mM NaCl, 1 mM TC...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBromodomain-containing protein 7(Homo sapiens (Human))
H. Lee Moffitt Cancer Center And Research Institute

Curated by ChEMBL
LigandPNGBDBM50266968(CHEMBL4065619 | US11773085, Compound B27)
Affinity DataKd:  316nMAssay Description:Binding affinity to BRD7 (unknown origin)More data for this Ligand-Target Pair
TargetBromodomain-containing protein 9(Homo sapiens (Human))
H. Lee Moffitt Cancer Center And Research Institute

Curated by ChEMBL
LigandPNGBDBM50266968(CHEMBL4065619 | US11773085, Compound B27)
Affinity DataKd:  32nMAssay Description:Binding affinity to BRD9 (unknown origin)More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM50266968(CHEMBL4065619 | US11773085, Compound B27)
Affinity DataKd: >990nMAssay Description:Binding affinity to human BRD4 BD1 (N44 to E168 aa residues) by bromoKdELECT Discover assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 9(Homo sapiens (Human))
H. Lee Moffitt Cancer Center And Research Institute

Curated by ChEMBL
LigandPNGBDBM50266968(CHEMBL4065619 | US11773085, Compound B27)
Affinity DataKd:  82nMAssay Description:Binding affinity to recombinant human His-tagged BRD9 (134 to 239 residues) expressed in Escherichia coli BL21 DE3 assessed as dissociation constant ...More data for this Ligand-Target Pair