BDBM50269979 CHEMBL515170::r-5-(2-E-cyclopropylvinyl)-t-3-ethyl-6,7-difluoro-5-(trifluoromethyl)benzo[e][1,4]-oxazepin-2(1H,3H,5H)-one

SMILES CC[C@@H]1O[C@@](\C=C\C2CC2)(c2c(F)c(F)ccc2NC1=O)C(F)(F)F

InChI Key InChIKey=MSJCAWWJIHDUAU-OSTNNTLRSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50269979   

TargetParathyroid hormone/parathyroid hormone-related peptide receptor(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50269979(CHEMBL515170 | r-5-(2-E-cyclopropylvinyl)-t-3-ethy...)
Affinity DataIC50:  6.80E+4nMAssay Description:Antagonist activity at PTH/PTH-related peptide receptor (unknown origin) expressed in HKRK-B28 cells assessed as inhibition of parathyroid hormone (1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50269979(CHEMBL515170 | r-5-(2-E-cyclopropylvinyl)-t-3-ethy...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of 5HT2A receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50269979(CHEMBL515170 | r-5-(2-E-cyclopropylvinyl)-t-3-ethy...)
Affinity DataIC50:  1.38E+4nMAssay Description:Inhibition of adrenergic alpha1D receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetParathyroid hormone/parathyroid hormone-related peptide receptor(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50269979(CHEMBL515170 | r-5-(2-E-cyclopropylvinyl)-t-3-ethy...)
Affinity DataIC50:  990nMAssay Description:Displacement of [125I]DPC-AJ1951 from PTH/PTH-related peptide receptor (unknown origin) expressed in HKRK-B28 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50269979(CHEMBL515170 | r-5-(2-E-cyclopropylvinyl)-t-3-ethy...)
Affinity DataIC50:  1.04E+4nMAssay Description:Inhibition of adrenergic alpha2C receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetParathyroid hormone/parathyroid hormone-related peptide receptor(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50269979(CHEMBL515170 | r-5-(2-E-cyclopropylvinyl)-t-3-ethy...)
Affinity DataIC50:  5.78E+3nMAssay Description:Antagonist activity at PTH/PTH-related peptide receptor (unknown origin) expressed in HKRK-B28 cells assessed as inhibition of DPC-AJ1951-induced cAM...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50269979(CHEMBL515170 | r-5-(2-E-cyclopropylvinyl)-t-3-ethy...)
Affinity DataIC50:  2.80E+4nMAssay Description:Inhibition of neurokinin 2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed