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BDBM50271573 1-[4-Chlorobenzyl]-4-[4-(pyridin-4-yl)phenylmethyl]-piperazine::CHEMBL482528

SMILES: Clc1ccc(CN2CCN(Cc3ccc(cc3)-c3ccncc3)CC2)cc1

InChI Key: InChIKey=IDJVQGABBCXBQJ-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50271573   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lanosterol synthase


(Homo sapiens)
BDBM50271573
PNG
(1-[4-Chlorobenzyl]-4-[4-(pyridin-4-yl)phenylmethyl...)
Show SMILES Clc1ccc(CN2CCN(Cc3ccc(cc3)-c3ccncc3)CC2)cc1
Show InChI InChI=1S/C23H24ClN3/c24-23-7-3-20(4-8-23)18-27-15-13-26(14-16-27)17-19-1-5-21(6-2-19)22-9-11-25-12-10-22/h1-12H,13-18H2
PDB
MMDB

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 316n/an/an/an/an/an/a



Laboratoire GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of 2,3-oxidosqualene-lanosterol cyclase (unknown origin)


Bioorg Med Chem 16: 6218-32 (2008)


Article DOI: 10.1016/j.bmc.2008.04.034
BindingDB Entry DOI: 10.7270/Q2M61K14
More data for this
Ligand-Target Pair