BDBM50273899 CHEMBL456823::tert-Butyl-4-[1-(2-fuluoropyridine-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-3,6-dihydropyridine-1(2H)-carboxylate

SMILES Cc1c(nnn1-c1ncccc1F)C1=CCN(CC1)C(=O)OC(C)(C)C

InChI Key InChIKey=INXYUZGZBZNQGF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50273899   

TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50273899(CHEMBL456823 | tert-Butyl-4-[1-(2-fuluoropyridine-...)
Affinity DataIC50:  7nMAssay Description:Antagonist activity at human mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50273899(CHEMBL456823 | tert-Butyl-4-[1-(2-fuluoropyridine-...)
Affinity DataIC50:  170nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Mus musculus)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50273899(CHEMBL456823 | tert-Butyl-4-[1-(2-fuluoropyridine-...)
Affinity DataIC50:  1.5nMAssay Description:Antagonist activity at mouse mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed