BDBM50274685 (3R)-(+)-8-Fluoro-3-[{[6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl]methyl}(propyl)amino]chromane-5-carboxamide::(3R)-(-)-8-Fluoro-3-[{[6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl]methyl}(propyl)amino]chromane-5-carboxamide::CHEMBL485579

SMILES CCCN(CC1CCc2[nH]c3ccc(F)cc3c2C1)[C@H]1COc2c(F)ccc(C(N)=O)c2C1

InChI Key InChIKey=UFSULTLEIKMZQU-OMOCHNIRSA-N

Data  4 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50274685   

Target5-hydroxytryptamine receptor 1A(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274685((3R)-(+)-8-Fluoro-3-[{[6-fluoro-2,3,4,9-tetrahydro...)
Affinity DataKi:  60.3nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 1A(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274685((3R)-(+)-8-Fluoro-3-[{[6-fluoro-2,3,4,9-tetrahydro...)
Affinity DataKi:  60.3nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium-dependent serotonin transporter(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274685((3R)-(+)-8-Fluoro-3-[{[6-fluoro-2,3,4,9-tetrahydro...)
Affinity DataKi:  181nMAssay Description:Displacement of [3H]paroxetine from serotonin transporter in Sprague-Dawley rat frontal cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium-dependent serotonin transporter(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274685((3R)-(+)-8-Fluoro-3-[{[6-fluoro-2,3,4,9-tetrahydro...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]paroxetine from serotonin transporter in Sprague-Dawley rat frontal cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium-dependent serotonin transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274685((3R)-(+)-8-Fluoro-3-[{[6-fluoro-2,3,4,9-tetrahydro...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of 5-HT transporter-mediated [3H]5HT uptake in human Jar cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium-dependent serotonin transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274685((3R)-(+)-8-Fluoro-3-[{[6-fluoro-2,3,4,9-tetrahydro...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of 5-HT transporter-mediated [3H]5HT uptake in human Jar cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 1A(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274685((3R)-(+)-8-Fluoro-3-[{[6-fluoro-2,3,4,9-tetrahydro...)
Affinity DataIC50: >1.00E+3nMAssay Description:Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 1A(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274685((3R)-(+)-8-Fluoro-3-[{[6-fluoro-2,3,4,9-tetrahydro...)
Affinity DataIC50:  181nMAssay Description:Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed