BDBM50276028 CHEMBL469514::N-(2-amino-5-(thiophen-2-yl)phenyl)-6-(1-oxo-2,8-diazaspiro[4.5]decan-8-yl)nicotinamide

SMILES Nc1ccc(cc1NC(=O)c1ccc(nc1)N1CCC2(CCNC2=O)CC1)-c1cccs1

InChI Key InChIKey=HWMRDBKBMQHAFV-UHFFFAOYSA-N

Data  1 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50276028   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50276028(CHEMBL469514 | N-(2-amino-5-(thiophen-2-yl)phenyl)...)
Affinity DataKi:  8.62E+3nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50276028(CHEMBL469514 | N-(2-amino-5-(thiophen-2-yl)phenyl)...)
Affinity DataEC50:  1.80E+4nMAssay Description:Activity at human ERG expressed in CHO cells by patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50276028(CHEMBL469514 | N-(2-amino-5-(thiophen-2-yl)phenyl)...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human HDAC1 expressed in mammalian cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed