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BDBM50276189 1-(2-Naphthyl)-2-aminopropane::CHEMBL471839

SMILES: CC(N)Cc1ccc2ccccc2c1

InChI Key: InChIKey=UPQSZFKXKRKCGZ-UHFFFAOYSA-N

Data: 2 KI  3 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50276189   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50276189
PNG
(1-(2-Naphthyl)-2-aminopropane | CHEMBL471839)
Show SMILES CC(N)Cc1ccc2ccccc2c1
Show InChI InChI=1S/C13H15N/c1-10(14)8-11-6-7-12-4-2-3-5-13(12)9-11/h2-7,9-10H,8,14H2,1H3
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PubMed
n/an/an/an/a 3.40n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Induction of 5-HTT-mediated 5-HT release in rat brain synaptosomes by [3H]5-HT release assay


Bioorg Med Chem Lett 24: 4754-8 (2014)


Article DOI: 10.1016/j.bmcl.2014.07.062
BindingDB Entry DOI: 10.7270/Q2416ZNK
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50276189
PNG
(1-(2-Naphthyl)-2-aminopropane | CHEMBL471839)
Show SMILES CC(N)Cc1ccc2ccccc2c1
Show InChI InChI=1S/C13H15N/c1-10(14)8-11-6-7-12-4-2-3-5-13(12)9-11/h2-7,9-10H,8,14H2,1H3
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PubMed
n/an/an/an/a 11n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Induction of NET-mediated norepinephrine release in rat brain synaptosomes by [3H]NE release assay


Bioorg Med Chem Lett 24: 4754-8 (2014)


Article DOI: 10.1016/j.bmcl.2014.07.062
BindingDB Entry DOI: 10.7270/Q2416ZNK
More data for this
Ligand-Target Pair
Monoamine Oxidase Type B (MAO-B)


(Rattus norvegicus (rat))
BDBM50276189
PNG
(1-(2-Naphthyl)-2-aminopropane | CHEMBL471839)
Show SMILES CC(N)Cc1ccc2ccccc2c1
Show InChI InChI=1S/C13H15N/c1-10(14)8-11-6-7-12-4-2-3-5-13(12)9-11/h2-7,9-10H,8,14H2,1H3
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B.MOAD
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PubMed
>1.00E+5n/an/an/an/an/an/an/an/a



University of Chile

Curated by ChEMBL


Assay Description
Inhibition of MAOB in rat brain mitochondria


Bioorg Med Chem 17: 2452-60 (2009)


Article DOI: 10.1016/j.bmc.2009.01.074
BindingDB Entry DOI: 10.7270/Q2KW5GZ3
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM50276189
PNG
(1-(2-Naphthyl)-2-aminopropane | CHEMBL471839)
Show SMILES CC(N)Cc1ccc2ccccc2c1
Show InChI InChI=1S/C13H15N/c1-10(14)8-11-6-7-12-4-2-3-5-13(12)9-11/h2-7,9-10H,8,14H2,1H3
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MMDB

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B.MOAD
DrugBank
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CHEMBL
PC cid
PC sid
UniChem

Patents


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Article
PubMed
420n/an/an/an/an/an/an/an/a



University of Chile

Curated by ChEMBL


Assay Description
Inhibition of MAOA in rat brain mitochondria


Bioorg Med Chem 17: 2452-60 (2009)


Article DOI: 10.1016/j.bmc.2009.01.074
BindingDB Entry DOI: 10.7270/Q2KW5GZ3
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50276189
PNG
(1-(2-Naphthyl)-2-aminopropane | CHEMBL471839)
Show SMILES CC(N)Cc1ccc2ccccc2c1
Show InChI InChI=1S/C13H15N/c1-10(14)8-11-6-7-12-4-2-3-5-13(12)9-11/h2-7,9-10H,8,14H2,1H3
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CHEMBL
PC cid
PC sid
UniChem

Patents


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Article
PubMed
n/an/an/an/a 13n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Induction of DAT-mediated dopamine release in rat brain synaptosomes by [3H]DA release assay


Bioorg Med Chem Lett 24: 4754-8 (2014)


Article DOI: 10.1016/j.bmcl.2014.07.062
BindingDB Entry DOI: 10.7270/Q2416ZNK
More data for this
Ligand-Target Pair