BDBM50276756 4,9-bis(3,5-dihydroxyphenoxy)benzofuro[3,2-a]dibenzo[b,e][1,4]dioxine-1,3,6,10,12-pentaol::CHEMBL510508::Phlorofucofuroeckol-A::US10106521, Compound Phlorofucofuroeckol A::phlorofucofuroeckol A

SMILES Oc1cc(O)cc(Oc2c(O)cc(O)c3Oc4c(Oc23)c(O)cc2oc3c(Oc5cc(O)cc(O)c5)c(O)cc(O)c3c42)c1

InChI Key InChIKey=SLWPBUMYPRVYIJ-UHFFFAOYSA-N

Data  2 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50276756   

TargetBeta-secretase 1(Homo sapiens (Human))
Pukyong National University

Curated by ChEMBL
LigandPNGBDBM50276756(4,9-bis(3,5-dihydroxyphenoxy)benzofuro[3,2-a]diben...)
Affinity DataKi:  1.30E+3nMAssay Description:Noncompetitive inhibition of human recombinant BACE1 after 60 mins by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Korea Research Institute Of Bioscience And Biotechnology

Curated by ChEMBL
LigandPNGBDBM50276756(4,9-bis(3,5-dihydroxyphenoxy)benzofuro[3,2-a]diben...)
Affinity DataKi:  1.06E+4nMAssay Description:Competitive inhibition of C-terminal His6-tagged recombinant SARS coronavirus 3C-like protease trans-cleavage activity expressed in Escherichia coli ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Korea Research Institute Of Bioscience And Biotechnology

Curated by ChEMBL
LigandPNGBDBM50276756(4,9-bis(3,5-dihydroxyphenoxy)benzofuro[3,2-a]diben...)
Affinity DataIC50:  1.67E+4nMAssay Description:Inhibition of C-terminal His6-tagged recombinant SARS coronavirus 3C-like protease trans-cleavage activity expressed in Escherichia coli BL21 (DE3) u...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Korea Research Institute Of Bioscience And Biotechnology

Curated by ChEMBL
LigandPNGBDBM50276756(4,9-bis(3,5-dihydroxyphenoxy)benzofuro[3,2-a]diben...)
Affinity DataIC50:  1.75E+5nMAssay Description:Inhibition of SARS coronavirus 3C-like protease cis-cleavage activity transfected in african green monkey Vero cells using SAVLQSGFRK as substrate af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Phloronol

US Patent
LigandPNGBDBM50276756(4,9-bis(3,5-dihydroxyphenoxy)benzofuro[3,2-a]diben...)
Affinity DataIC50:  9.41E+4nMpH: 7.4 T: 2°CAssay Description:Enzyme activities were determined at room temperature. Ultraviolet absorbance was measured spectrophotometrically by a modification of a previously d...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Pukyong National University

Curated by ChEMBL
LigandPNGBDBM50276756(4,9-bis(3,5-dihydroxyphenoxy)benzofuro[3,2-a]diben...)
Affinity DataIC50:  2.13E+3nMAssay Description:Inhibition of human recombinant BACE1 after 60 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Phloronol

US Patent
LigandPNGBDBM50276756(4,9-bis(3,5-dihydroxyphenoxy)benzofuro[3,2-a]diben...)
Affinity DataIC50:  1.00E+3nMpH: 7.4 T: 2°CAssay Description:Enzyme activities were determined at room temperature. Ultraviolet absorbance was measured spectrophotometrically by a modification of a previously d...More data for this Ligand-Target Pair
In DepthDetails US Patent