BDBM50277320 4-(pyridin-4-ylmethylamino)-N-(4-(trifluoromethyl)phenyl)isothiazole-3-carboxamide::CHEMBL475704

SMILES FC(F)(F)c1ccc(NC(=O)c2nscc2NCc2ccncc2)cc1

InChI Key InChIKey=DNCXMRGFMSYEIC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50277320   

TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Decode

Curated by ChEMBL
LigandPNGBDBM50277320(4-(pyridin-4-ylmethylamino)-N-(4-(trifluoromethyl)...)
Affinity DataIC50:  250nMAssay Description:Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Decode

Curated by ChEMBL
LigandPNGBDBM50277320(4-(pyridin-4-ylmethylamino)-N-(4-(trifluoromethyl)...)
Affinity DataIC50:  210nMAssay Description:Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Decode

Curated by ChEMBL
LigandPNGBDBM50277320(4-(pyridin-4-ylmethylamino)-N-(4-(trifluoromethyl)...)
Affinity DataIC50:  1.53E+3nMAssay Description:Inhibition of VEGFR2 (unknown origin) expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed